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New FDA Warnings for Psychiatric Drug Side Effects

Here are the most recent drug related drug warnings posted by the FDA. Not all of these drugs are psychiatric meds but quite a few are. Please read the new warnings and tell your friends who are on or considering taking any of these drugs to become informed. Most likely their doctor either won't know about these warnings or will downplay them based on pharmaceutical representative's sales pitches.

Richard

Subject: FDA MedWatch - August 2008 Drug Safety-Related Labeling Changes for 41 Drugs Now Available on Web

The August 2008 posting includes 41 drug products with safety labeling changes to the following sections: BOXED WARNING, CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, ADVERSE REACTIONS, and PATIENT PACKAGE INSERTS.

The "Summary Page" provides a listing of drug names and safety labeling sections revised:

http://www.fda.gov/medwatch/safety/2008/aug08_quickview.htm

The "Detailed View Page" identifies safety labeling sections and subsections revised along with a brief summary of new or modified safety information to the BOXED WARNING, CONTRAINDICATIONS, and/or WARNINGS sections:

http://www.fda.gov/medwatch/safety/2008/aug08.htm

In August 2008, the following drugs had modifications to the BOXED WARNING and/or CONTRAINDICATIONS sections:

Abilify (aripiprazole) online pharmacy, Abilify Discmelt (aripiprazole) Orally Disintegrating Tablets, Abilify (aripiprazole) Oral Solution, and Abilify (aripiprazole) Injection For Intramuscular Use Only

Clozaril (clozapine HCl) Tablets

FazaClo (clozapine) Orally Disintegrating Tablets

Geodon (ziprasidone HCl) Capsules and Geodon (ziprasidone mesylate) for Injection - For IM Use Only

Haldol (haloperidol injection) For Immediate Release

Haldol Decanoate (haloperidol) For IM Injection Only

Invega (paliperidone) Extended-Release Tablets

Moban (molindone hydrochloride tablets, USP)

Navane (thiothixene capsules) and Navane (thiothixene hydrochloride concentrate)

Risperdal (risperidone) Tablets, Risperdal (risperidone) Oral Solution, and Risperdal M-Tab (risperidone) Orally Disintegrating Tablets

Risperdal Consta (risperidone) Long-Acting Injection

Seroquel (quetiapine fumarate) Tablets

Seroquel XR (quetiapine fumarate) Extended-Release Tablets

Symbyax (olanzapine and fluoxetine HCl capsules)

Viread (tenofovir disoproxil fumarate) Tablets

Zyprexa (olanzapine tablets), Zyprexa Zydis (olanzapine orally disintegrating tablets), and Zyprexa IntraMuscular (olanzapine for injection)

Metadate CD (methylphenidate HCl, USP) Extended-Release Capsules

Reyataz (atazanavir sulfate) Capsules

Rocephin (ceftriaxone sodium) For Injection

Men’s Sexual Health – Natural Herbs to Put the Flip back into your Flop

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Even the most healthy, most alpha among males at some time or other failed to rise to the occasion. Potency is at the core of being male and can affect everything from self confidence to general health and well being. Sexual impotence, on the other hand, has been the cause of much embarrassment and discomfort to many. It is a topic that most do not honestly discuss with peers and even less with partners. In fact, so private and personal is this topic, that many become suckers to peddlers of fancy elixirs and formulas only to realized after an out of pocket experience, that information is readily available for all who need it.

You are not alone. It is important to know that more than 40 percent of all men over the age of 35 will experience some form of impotence (chronically known as erectile dysfunction). The floundering frequency increases with age, disorders and diseases, both physical and psychological. Of course a healthy lifestyle, exercise and a lack of support for vices like smoking, excessive drink and drug use all help to maintain high libido and good sexual health, but does not guarantee that you will never flop instead of flip. We aren’t all, unfortunately in the best of health nor destined to stand erect every time we need to heed the call.

Many products have been scientifically formulated to deal with the problem of erectile dysfunction. Even if you just returned from your intergalactic trip, it would be difficult not to know of the presence of products like Viagra and order cialis. Little magic pills brought and place in the wallet as part of our “power man” arsenal. BUT! Like the cigarette pack message, these bliss bullets can back fire with side effects. The use of such aids comes with their share of documented problems, including vision, blood pressure and painful joints, to mention a few. For some a few hours of pure pleasure and prowess outweighs the risks. Are you one to risk your health for a few hours of proven manhood? You don’t have to be. There have been, for centuries, natural plant extracts and mixtures safely address our drooping muscles, and the consensus, no real side effects.

Remember though, for peak potency and performance, exercise and a healthy diet is paramount. Many of your flaccid failures may be linked to underlying health issues, so before an emboldened move to conquer the queen, seek some advice from a health care pro. You can take safe action to toughen you tool with some of the following herbs and roots traditionally used to keep you alert at attention. I should also make it clear not to expect instant magic from most of these plants, but be prepared to follow a course of use for at least 3 weeks.

Look out for recipes, tinctures and mixtures in my future posts. Let’s hear what you think, leave a comment. My friends be safe, and keep her happy!

Catuaba Bark (Erythroxylum catuaba)
Harvested in Brazil from a tree found in the Amazon. Traditionally used to enhance libido, improve memory, and remove fatigue and pain. Generally, the catuaba bark comes from the Erythroxylum catuaba tree, but catuaba also refers to a decoction (tea) made with a collection of different barks and herbs. Scientific test have been done and results some degree of effectiveness as an aphrodisiac and a sexual enhancer.

Eleuthero Root (Eleutherococcus senticosua)
Also know as Siberian ginseng, a cousin to panax ginseng is no strange to the west as a herb used for rejuvenating and strengthening the body. It improves breathing capacity and gives the immune system a boost. It is a great endurance herb.


Epimedium (Epimedium Grandiflorum)
Known to many as horny goat weed is a ground shrub that grows in China. This herb appears to work much like the drug Viagra by inhibiting the PDE-5 enzyme, allowing for lengthier erections. Epimedium is also used to treat a host of other conditions including bronchitis, congestive heart failure and viral infections of the heart.


Sarsaparilla (Smilax ornate)
There are a few varieties of this root herb including strains from India, Mexico and Jamaica. There are major claims that it improves libido and increases sexual appitite. It is also said to be beneficial for the treatment of skin conditions such as psoriasis and eczema. Used with some other herbs, it is said to make sex more pleasurable.



Muira Puama Bark (Ptychopetalum olacoides)
Found in the Amazon, this is a powerful bark used traditionally by native Brazilians to treat sexual debility, weakness and hair loss. Tinctures of Muira puama are known to be effective and should be taken in moderation. This is another herb that works like the major drugs on the market, but without the same side effects.

Maca Root (Lepidium mayenil)
This is a root tuber grown originally in high in the Andes of Peru. It is touted for its ability to improve sexual endurance, physical stamina and elevate sperm production.




Yohimbe Bark (Pausinystalia yohimbe)
An evergreen tree native to Africa. The bark of this tree is used as an effective remedy to treat erectile dysfunction in men with diabetes and heart disease. Document studies have shown that it also increases libido. Men on blood thinning medication should be careful with this bark.


All of the above herbs can be found at http://www.mountainroseherbs.com
Natural herbal pills for treating ED can be at Indian herbs

First-Line Therapies

Proton-Pump-Inhibitor–Based Triple Therapies
• Treatment of H Pylori twice daily for seven days with 20 mg of omeprazole, given either with 1 g of amoxicillin and 500 mg of clarithromycin, or with 400 mg of metronidazole and 250 mg of clarithromycin [16].
• Several comparative trials have demonstrated the equivalence of 30 mg of lansoprazole twice daily, 40 mg of pantoprazole twice daily, 20 mg of rabeprazole daily, and 20 mg of esomeprazole twice daily with omeprazole in these triple therapies [16].
• The duration of therapy remains controversial. In Europe, 7-day treatment is recommended,whereas in the United States, 14-day courses have been found to be better than shorter courses and are approved by the FDA. In a recent meta-analysis, 14-day treatment achieved rates of cure 7 to 9 percentage points better than 7-day treatment [16].
• Primary resistance to clarithromycin and metronidazole decreases rates of cure by 50 percent and 37 percent, respectively [16].

Ranitidine Bismuth Citrate–Based Therapies
• Ranitidine bismuth citrate in dual therapy with clarithromycin for two weeks has been approved by the FDA [16].
• Bismuth citrate with clarithromycin and amoxicillin, or with clarithromycin and a nitroimidazole, performs as well as corresponding proton-pump-inhibitor–based therapies [16].
• Ranitidine bismuth citrate–based regimens may be less influenced by antibiotic resistance than their proton-pump-inhibitor–based counterparts. No ranitidine bismuth citrate–based triple therapy has been approved by the FDA [16].

Bismuth-Based Triple Therapies
• A proton-pump order cialis, clarithromycin, and either amoxicillin or metronidazole for two weeks; ranitidine bismuth citrate, clarithromycin, and amoxicillin, metronidazole, or tetracycline for two weeks; and a proton-pump cheap cialis, bismuth, metronidazole, and tetracycline for one to two weeks had been approved earlier [16].
• The regimens recommended by the European Maastricht 2–2000 conference are a proton-pump inhibitor (or ranitidine bismuth citrate), clarithromycin, and amoxicillin or metronidazole for seven days [16].
Second-Line Therapies
• Eradication is more difficult when a first treatment attempt has failed, usually because of either poor patient compliance or the development of antibiotic resistance. Therefore, a 10-to-14-day treatment course is advocated for second-line therapies [16].
• However, the optimal strategy for retreatment after the failure of eradication has not yet been established [16].
• Because the failure of therapy is often associated with secondary antibiotic resistance, retreatment should ideally be guided by data on susceptibility. However, such information is often unavailable, so quadruple therapies, in which a proton-pump inhibitor or an H2-receptor antagonist is added to a bismuth-based triple regimen with high-dose metronidazole, have been suggested as optimal second-line therapy [16].
• Another approach to retreatment without susceptibility testing is to prescribe a second course of proton-pump-inhibitor–based triple therapy, avoiding antimicrobial agents against which prior therapy may have induced resistance and avoiding less effective combinations, such as amoxicillin and tetracycline [16].
• If a clarithromycin-based regimen is used first, a metronidazole-based regimen should be used afterward, or vice versa [16].
• Alternative approaches to second-line proton-pump-inhibitor–based therapies have been reported recently, but mostly in abstract form. Rifabutin, given in association with amoxicillin and pantoprazole for 10 days, achieved an 86 percent rate of cure, even in patients with resistant strains [16].
• Regardless of which therapy course is chosen, patients with significant symptoms at presentation may continue to use a standard dose of a PPI for 3 extra weeks at the end of the combination drug treatment. The optimal rates of eradication are obtained within 14-day dosing but 7-day dosing are almost similar
Patients on nonsteroidal anti-inflammatory drugs (NSAIDs)
• Patients on NSAIDs should have these discontinued if possible.
• If it is not possible to discontinue NSAIDs, duration of PPI therapy of 12 weeks is recommended.
• In person with symptoms and risk factors, refer for endoscopy [14].
• If ongoing symptom relief is needed [14]:
• Continue NSAID with co prescription of PPI or misoprostol OR
• Replace NSAID with cyclo-oxygenase-2 (COX-2) selective inhibitor.

• Eradicate H. pylori if testing is positive [14].